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Anti-smoking ‘wonder pill’ to be given on the NHS

May 31, 2007

An anti-smoking “wonder pill” which is twice as effective as other treatments, looks likely to be made available on the National Health Service.

Tests showed that nearly half of patients who took Champix gave up smoking within three months.

Now the government’s “rationing” watchdog the National Institute for Health and Clinical Excellence has issued draft guidance that the drug, which costs £2 a day, should be available on prescription.

Champix works on the ‘pleasure centre’ of the brain, reducing the feeling of satisfaction smokers get from a cigarette and relieving cravings and other withdrawal symptoms.

After three months of treatment, 44 per cent of smokers using it had given up, double the proportion who found success with Zyban, another anti-smoking pill available on the NHS.

It was also twice as effective as those on nicotine replacement therapy. Trials on 2,000 people found that after a year, 22 per cent had still not started smoking again.

The twice-daily pill, also known as varenicline tartrate, would cost the NHS £163.80 for the recommended 12-week course.

But patients would be able to ask their GP for a course for a prescription charge of just £6.85.

In February, the Daily Mail launched a campaign to end NICE restrictions on three drugs to treat Alzheimer’s disease that cost £2.50 per day, just 50p more than Champix.

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NICE’s draft guidance is out for consultation. If there are no major objections, it will take effect in July, just after England goes smokefree on July 1, when a ban on smoking in virtually all enclosed work and public places comes into force.

A spokesman for NICE said: “Having looked at all the evidence, our independent committee has concluded that it appears to be a good way to help people who want to quit smoking.

“The draft guidance also recommends that varenicline should normally be provided in conjunction with counselling and support, but if such support is not available, this should not stop smokers receiving treatment with varenicline.”

Most anti-smoking treatments work by supplying the body with a steady stream of nicotine through skin patches, chewing gums or inhalers, allowing the craving to gradually diminish.

Champix, however, is nicotine-free. It works by binding to nicotine receptors in the brain and reducing the severity of cravings.

It also reduces the satisfaction gained from smoking by interfering with the brain’s production of the chemical dopamine, which is associated with pleasure.

The Champix molecule is based on a chemical found in the leaves of the cytisus laburnum tree, which was used as a tobacco substitute by soldiers in the Second World War.

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Viagra empire run from prison

May 29, 2007

A SALESMAN who became the first in Britain to be jailed for illegally selling drugs – including Viagra – on the internet is still running his business from behind bars, the M.E.N. can reveal today.

Martin Simon Hickman , of Ashton under Lyne, was sentenced to three months and fined £20,000 for contempt of court at the High Court of Justice earlier this month.

He had was given the prison term after he failed to abide by a previous High Court injunction ordering him to stop selling drugs including Viagra – which is can only be available on prescription – and the similar but unlicensed Kamagra on the internet.

Hickman, from Ashton under Lyne, is the first retailer in Britain the UK to be jailed after a civil action by the Medicines and Healthcare products Regulatory Agency.
(MHRA).

But within days of him going to jail, the M.E.N. ordered Kamagra tablets – a generic and cheaper version of Viagra – online from his company’s website.

Our investigator was sent a batch of `Lovegra’ tablets, which is another name for Kamagra. They were offered on a deal where we bought eight tablets and were given another eight `free’ at a total cost of £32 plus £5 postage and packing.

Hickman’s website offers free delivery but we paid extra to ensure fast delivery and received an order within a few days. The drugs were dispatched via a PO Box address in Ashton.

Side effects

Experts say that if the drugs are taken without an initial assessment by a GP, users run the risk of suffering serious side effects - including a heart attack.

Hickman’s website offers a wide-range of `erectile dysfunction’ medication and boasts there are no prescription, consultation or administration charges. It will supply a maximum of three months’ medication in one order.

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Enclosed in the package delivered to us was a leaflet which warns that prescription medicines can only be taken by the person they are prescribed for.

It adds that a person must have `no medical condition to restrict the taking of the medicine’ and if in doubt you should contact your GP before taking it. The leaflet also contains a liability disclaimer.

Hickman was investigated by the MHRA - the government agency which is responsible for ensuring the safety of medicines - after his website was found to be offering the drugs for sale.

A test purchase was made and Hickman was then warned on several occasions that he was breaking the law and that he should stop advertising certain medicines for sale.

He was threatened with legal action and finally issued with a High Court injunction last September. Investigators believe Hickman had several websites, including one which was hosted in Germany.

Hickman was jailed on May 7 and his company MSH Traders fined £20,000 after he was found to be in contempt of court for failing to observe the High Court injunction.

The Right Honourable Justice Saunders described Hickman as a `wholly unbelievable witness’.

When the M.E.N. told the MHRA of our purchase, a spokeswoman said: “We take a very dim view of this. We are investigating and look forward to receiving your evidence.”

She added: “When people buy these products in this way they could be buying counterfeits so they are being ripped off. Secondly, taking the tablets could be dangerous.”

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Hamsters on Viagra have less jet lag

May 24, 2007

Hamsters given Pfizer Inc.’s Viagra adapted more quickly to changes in their internal clocks, scientists said.

Hamsters given sildenafil, the chemical name of the drug sold as Viagra, adapted more easily to altered patterns of light exposure to simulate changes caused by air travel across time zones. Long-haul travel desynchronizes the body’s alignment to the day-night cycle, leading to the disorientation of jet lag.

A person traveling east experiences difficulty falling asleep and awakening; a person traveling west falls asleep and awakes earlier, according to the Centers for Disease Control and Prevention in Bethesda, Maryland. Viagra helped the hamsters with eastward travel, said head researcher Diego A. Golombek, a scientist with the Laboratorio de Cronobiologica in Buenos Aires.

“Because Viagra is widely used, it’s something we can easily imagine being useful,” said Christopher Colwell, an associate professor of psychiatry at the David Geffen School of Medicine at the University of California Los Angeles. “This study is very cool — not a huge surprise, but a neat proof of principle.”

Most drugs that can be used to mimic circadian rhythms “you wouldn’t want to take yourself,” Colwell said, citing unwanted side-effects. He wasn’t involved in the study. “This could be applied to humans pretty easily.”

Hamster rhythms
Hamsters are the species of choice for studies of circadian rhythms, Golombek said. That’s because they have precise patterns, which are easily measured by watching when they run on their exercise wheels.

“As anyone who has a hamster as a pet will attest, they go to the wheel at the same time every night,” Golombek said. “They love wheels.”

The researchers synchronized the hamsters to a 24-hour day by simulating light-dark cycles. Once the hamsters adjusted to a cycle, they shifted the light-dark phases forward six hours. One group of hamsters was given saline; the other was given Viagra. The hamsters given Viagra got used to the change 4 days faster, on average, than their counterparts given a placebo. Viagra eased the transition that mimicked crossing the international dateline from west to east, known as phase advancing, and had no effect on a transition that mimicked westward travel.

“All animals, including humans, have a harder time with phase advancing,” said Colwell in a telephone interview today. “Humans are unique in our ability to screw up our timing system — you know, jet lag, shift work, staying up too late playing video games, or whatever.”

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Viagra for angina
Viagra was initially developed for angina, which is chest pain that occurs when the heart muscle doesn’t get enough blood. The same chemical, marketed under the name Revatio, is used to treat pulmonary arterial hypertension. Another study recently showed that the drug may help in treating idiopathic pulmonary fibrosis.

Viagra keeps another chemical in the brain, called cyclic GMP, from decomposing. Because cyclic GMP is involved in adapting to light, the researchers hypothesized that increasing its levels would accelerate animals’ adaptation to a new schedule.

The researchers performed the study with several dosage levels of Viagra, Golombek said. Low doses elicited a circadian response and had no erectile effects; at higher doses, Viagra stimulated both the circadian rhythms and the hamsters’ penises. It’s difficult to compare hamster dosage with human dosage because hamsters have a faster metabolic rate, Golombek said.

“This research is particularly relevant since it opens a completely original way of dealing with” jet lag, Golombek said.

Though Viagra is typically prescribed to men, there is no reason to think that it wouldn’t be equally effective in women for jet lag, Colwell said.

“Every bit of our biology is influenced by our timing system,” Colwell said. “We have a clock inside us, and in order for us to work properly, it has to be synchronized with the environment.”

Human Trials Needed

The researchers said studies hadn’t been performed in humans and that clinical trials must be undertaken before Viagra is considered a safe and useful treatment for the condition.

“Jet lag trials might involve laboratory simulations, but we also need the real thing,’ which means testing pharmacological treatments on long-haul air travel, which will certainly take some time,” Golombek said.

Pfizer, the world’s largest drugmaker, had no connection to the study.

“While this is an interesting area of research, Pfizer has not conducted any trials assessing Viagra use as a treatment for jet lag and has no plans to do so,” Pfizer spokesman Francisco Gebauer said in an e-mailed statement today. “Viagra is approved only for the treatment of erectile dysfunction.”

Viagra did $434 million in sales the first quarter of 2007, an 11 percent increase from the first quarter of 2006. It is the New York-based drugmaker’s fifth-largest product.

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New hopes for a female Viagra

May 21, 2007

DALLAS — More than seven years after Viagra hit the market, women are still asking: “What about us?”

Now, what Viagra did for men, a new drug being studied could do for a woman’s sex drive.

For years, low libido in women has been blamed on the laundry, the soccer games, the dishes and life in general.

While that may be partially to blame, millions of women have questioned how they can love their partners and spouses, but lose interest in their sex drive.

“Is this normal, what’s wrong with me, what can I do to make it better?” asks one woman, who preferred to not be identified. “Then you start getting into insecurities. What’s this going to do to my marriage, what are all the other women doing about this.”

Until now, the answer has been - nothing.

That’s why the clinical trial of a new drug is exciting - both to potential patients and doctors.

It was originally investigated as an anti-depressant.

“But it didn’t work well,” says UT Southwestern gynecologist Bruce Carr. “Now the company that was investigating it was going to shelve it but they found when they looked at the data that the women that had taken it, one of the side-effects is increased sex drive, or increased libido.”

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Dr. Carr is among the investigators of Flibanserin - a daily medication to improve a woman’s sex drive.

Last year, the FDA refused to approve Intrinsa, a testosterone patch for women.

Instead of increasing hormone levels, Flibanserin targets the pleasure zones of a woman’s brain.

For this phase three study, researchers are looking for pre-menopausal women, between 18-to-45 years old, in a stable, heterosexual relationship, with no other serious medical conditions.

Doctors say if it works, Flibanserin will help women and men.

“It’ll hope both,” says Dr. Carr. “It’ll help fulfill their [a woman’s] needs and also their husband’s needs and it could really improve relationships.”

That’s why this North Texas mother and wife enrolled.

“I’m doing it for me, I’m doing it for my husband really. Partly because I’m trying to figure out if something’s wrong with me that can be fixed,” she says. “I’m hopeful.”

She doesn’t know if she’s getting the real medication, or a placebo. Nor would she reveal if she’s experiencing an improvement in sex drive.

But she knows many other women are also hoping this drug can do for them what Viagra did for men’s sex lives.

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Pfizer CFO, Research Head to Leave

May 21, 2007

NEW YORK — Jeffrey Kindler, the chief executive of the world’s largest drug maker Pfizer Inc., continued to clean house with the announcement late Sunday that the company’s research and development chief and chief financial officer will soon leave.

The news comes as the company seeks to cut 10,000 jobs, or 10 percent of its work force, as it tries to boost profits with tepid sales anticipated in the near future. Kindler, the architect of the company’s transformation, became Pfizer’s CEO and chairman last year.

John LaMattina, the longtime president of global research and development, will retire from the company by the end of the year, Pfizer said. The company’s chief financial officer, Alan Levin, also resigned.

Pfizer said both executives have agreed to remain at the company during the search for their replacements.

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LaMattina, 57, has been with the company since 1977 and, as the head of research and development, was tasked with keeping Pfizer’s product line vital. Levin, 45, took over as chief of finance in 2005. He said in a statement that he felt after 20 years of service with Pfizer it was the “appropriate time for me to explore career opportunities outside of the company.”

Kindler credited LaMattina with building the company’s early- and mid-stage drug pipelines. The company has about 50 candidates in early stage development and about 30 in mid-stage development. Early stage drugs take an average eight and a half years to make it to a possible Food and Drug Administration approval, and mid-stage drugs are an average of seven years away. The company has a handful of drug candidates in late-stage development.

Pfizer is facing tough challenges. Analysts are skeptical that the maker of Lipitor and Viagra can generate enough sales from current and pipeline products to counter billions in sales that will be lost because of expiring patents on key drugs.

“We intend to make our internal capability even more effective by tapping into the best scientific capability outside our walls wherever it exists,” Kindler said Sunday in the statement announcing the leadership changes.

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No Viagra revolution

May 16, 2007

WASHINGTON | When Viagra came on the market nine years ago, Time magazine worried that it signaled “the end of sex as we know it.”

Adweek forecast demand for Viagra so massive that “not one dollar need ever be spent advertising it.”

It certainly hasn’t worked out that way.

Prescriptions for erectile dysfunction drugs, which sparked a rush to doctors’ offices initially, have been steady worldwide for three years despite massive promotional campaigns. Revenues for Viagra were once forecast at $5 billion a year. In 2006, revenues totaled $3 billion for Viagra and rivals Levitra and Cialis combined.

“The market’s about as big as it’s going to get,” said Jason Napodano, a biotech stock analyst at Zacks Equity Research in Chicago.

So the first finding about how erectile dysfunction drugs changed American life is: less than expected. Rather than spark a second sexual revolution, sexologists say, Viagra and its cousins merely advanced a trend toward enhanced and open sensuality.

The drugs made erection problems widely discussable for the first time. They made chemically assisted sex acceptable among law-abiding people. They enhanced the potential for sex among older Americans. For younger ones, the drugs reportedly made dating life more ardent, stressful and sex-centered.

For promiscuous gay men, the drugs probably made pleasure riskier: Surveys show that users have more sex and sexually transmitted diseases. For women, sex therapists say, the drugs made intimacy more intercourse-centered and more time-regimented.

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For every man with erectile dysfunction who has sought treatment, several more never have, surveys determined, and that more than anything suppressed the market for the drugs.

And those who did try the drugs had mixed results.

Drugmakers say there are 30 million men with erection problems in the U.S., 52 percent of men ages 40 to 70.

The best estimate is that a fifth or sixth of men with erectile dysfunction now take the drugs, which usually work.

An AARP sexuality survey of men and women ages 45 and older show that men treated for erectile dysfunction reported that they had more and better sex. In addition, 56 percent of the men said it had improved their relationships. Virtually all the rest said that treatment — mostly but not always with drugs — neither helped nor hurt their relationships.

For a second large group — younger men who take the drug to enhance performance — results are more mixed. A third very large group consists of men who tried the drugs but only briefly.

About half of men for whom erectile dysfunction drugs are prescribed don’t renew their prescriptions, surveys indicate.

The drugs produce erections about 4 out of 5 times when the problem is psychological, according to their makers, 2 out of 3 when it is organic. Alcohol or a heavy dinner can add to the failure rate, however. Side effects, such as headaches and nausea, can be discouraging.

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For women, Viagra can have psychological consequences

May 15, 2007

WASHINGTON –
When Pfizer’s market strategists were shaping attitudes toward Viagra in the late ’90s, they had little to say to women. That seems to have been a mistake, and a factor in unimpressive sales in recent years.

The campaign had just one goal: to destigmatize impotence in men so they’d talk to their doctors about the problem and ask for Viagra.

The effort succeeded. Viagra’s 1998 launch was the most successful drug introduction ever.

But aside from telling women that a drug to fix erectile dysfunction existed, which many found to be great news, the campaign gave no role or voice to the partner who sex therapists say usually controls intimacy.

At the same time, Viagra required women to buy into a strict new lovemaking time regimen: roughly an hour’s wait before the drug took effect and then sex before it wore off in four to six hours.

In theory, prescribing doctors would counsel couples, bringing women into the picture. In practice, time-strapped internists and general practitioners — who, studies say, do 75 percent of ED drug prescribing — often see only the men.

Dr. Abraham Morgentaler, the author of the book The Viagra Myth: The Surprising Impact on Love and Relationships, thinks that many women never fully endorsed the drug for use in their love lives.

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“Often, it doesn’t fit their idea of what sex should be,” he said. “It’s not spontaneous; it’s not romantic; there’s planning involved. Or the woman wonders, ‘Why does my husband need a pill to have sex with me? Why am I not enough?’” (Not surprisingly, Viagra’s most successful competitor is Lilly ICOS’s Cialis, whose ads show blissed-out couples and tout the drug’s 36-hour window for sex.)

Feminists raise more basic objections to the drugs. Dr. Leonore Tiefer, for example, an associate professor of psychiatry at the New York University School of Medicine, argues that the drugs promote intercourse-focused sex at the expense of other forms of lovemaking that women often find more gratifying.

She and many other clinicians say the drugs’ makers reduce the rich complexity of sex by defining it as a strictly physical event in order to sell a pharmaceutical solution when it fails. Their term for what the industry is marketing is “medicalized” sex.

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A tale of sex parties, online escorts and malfunctioning e-penises.

May 10, 2007

Outside, fifteen or so people are on the open-air dancefloor, talking, moving to a beat, enjoying themselves. It’s a nice evening. The sun has yet to set, music plays, and couples are gradually drifting indoors. From the outside, this is a conventional party and one of many similar social gatherings currently taking place in the online world of Second Life. The view from inside the house, however, tells a radically different story.

This is one of Second Life’s numerous free sex clubs, a never-ending party where people can meet, dance and, if they happen to hit it off, move swiftly on to the next stage. Poseballs - switches that trigger character animations - are everywhere. But while these are normally used for animating everything from eating to playing pool, here they enable up to four people to join together in an array of lascivious combinations. I’ve come here to start my journey through the world of virtual sex: to find out where it happens, how it happens, and why it happens.

Second Life is a world apart from most MMO games. For a start, it’s not a game. With no goal and no specific mandate, developers Linden Labs have instead created the tools necessary for users to make their own fun. The community has created the architecture, the clothes, the animations and the code that make SL such a fascinating place to visit.

Where such freedom exists, sex is sure to follow. For most, it’s not a concern, merely another oddity in an already colourful world. For others, it’s the entire reason for being here.

There are those who write the code that make it possible, and those who become strippers and prostitutes to make it easy. There are those for whom it’s a way of life, and there are those for whom it’s a genuine, emotive expression of love. Mainly, though, it’s a community of explorers and fetishists, and of curious gamers looking for a cheap, thoughtless thrill.

Sex in Second Life is more than mere mimicry of the real world: it’s an entire industry unto itself. Here, in the bottom floor of this mansion by the sea, among the finely coiffed and immaculately undressed, my avatar looks gormless and crude. Designed primarily by hitting the randomise button too many times on the character creation screen and infused with life by clumsy, default animations, I look like an overly-stretched man stumbling with the wandering gait of Frankenstein’s monster.

It’s with this lumbering momentum that I’ve approached a naked man I don’t know in a house I’ve never been to before, and it’s with dead eyes that I’m enquiring about where I can purchase genitalia.

Let me explain. While Linden Labs haven’t discouraged sexual conduct, they haven’t encouraged it either. Avatars are as anatomically correct as Ken and Barbie dolls. If you like your salacious simulacra to be as accurate as possible, you have to purchase one of the many available devices that turn your empty plate into a full meat and two veg.

The man I’m talking to has his equipment in full view, and I’m banking on him being able to help me. “Where do you get the cock and balls?” I ask again. He explains that they’re sold in stores around the world. I’m aware of that, but don’t know where any such stores are. Luckily, he then offers to sell me one. Or a pair. Or a set. I’m not sure. A plate-full, anyway.

He suggests 400 Linden dollars - the in-game currency. That’s around 75p. It seems more than reasonable, until from the other side of the room another man, decked head to foot in leather, speaks up: “I’ll sell you a penis for 350 Lindens.” Sold! I can’t resist a thrifty bargain. We make the exchange and I slip off to an empty room to try it on for size. But my frugality did not serve me well: my new genitalia are a mere novelty, seemingly struck with a permanent case of rigor mortis. To have such a thing in real life would cause you to pass out from lack of blood to the brain.

You want a piece of me? Huh? Do ya? That’ll be £5, please.
Putting it away, I look for the original seller. Much to my relief, he’s still downstairs in the living room, as naked as the day he created himself.

I make my purchase for the original price of 400 Lindens, and return to the back room. This time, the landing gear is down in the proper position when attached, and upon clicking on my new friend, a message appears. “Graham Vantongerloo’s ‘FuckStick’ Xcite! You are playing with FuckStick. What would you like to do?”

Xcite! are a team of designers committed to bringing to Second Life an entire range of products meant to aid the act of coitus. They’re not the only ones working on such things, but their products are some of the most advanced and popular available.

Below the message is a series of buttons, each clearly marked: Adjust, Masturbate, Stop, Options and Ignore. I choose Adjust, since in its current placement my testicles hang not between my legs, but somewhere around mid-thigh on my right leg. Shifting them to one side slots them perfectly into position.

The Options button reveals even greater customisation: everything from changing its name, sounds, colour and visibility, to making it numb. But what’s most impressive is the realism. For one thing, it’s limp until touched, and gradually stiffens as you or someone else grapples with it. For a second thing, it actually climaxes, with suitable particle effects and all. Following that is referred to in the manual as a “refractory period,” during which standing at attention, while not impossible, will be far more difficult.

My previous attachment was static, but this? This is a beautiful piece of engineering; a fully functional, tantalising, romanticising, surprising, her-prizing interactive love machine designed to simulate, stimulate, and titillate. It is, in every sense, the very model of the modern Major General.

Or so I thought.

The free party I arrived at is just one of the numerous popular locations that show up when you search for ’sex’ and related terms in Second Life, and whether you’re looking for toys, escorts or strippers, there’s always plenty available. To continue my quest, I decide to look for something else I have heard about but never actually seen - hooker malls.

The one I teleport to is open air, and looks like an E3 convention floor with the games removed and only the booth babes left. In three-walled compartments, girls stand around poles, throwing poses and attempting to get the attention of a small, wandering group of people. Flashy posters advertise girls not present who are nevertheless available for hiring. A dynamic bar at the bottom of each picture lets shoppers know if the girl is on- or offline.

It’s here that sex is most clearly commoditised: women turned into merchandise for the sake of visiting shoppers. But while seemingly dehumanising, it is also the perfect picture of modern consumerism. This is not a seedy backalley or a street corner in a rundown part of town. It’s a brightly lit shopping centre: a clean, consumer paradise with sunshine and flowers. The setting is the antithesis of traditional ideas of where the sex trade should take place, and it’s an obvious reminder that the ins and outs of virtual sex are not the same as the real thing. How dehumanising is this really? After all, these aren’t real humans on display in the first place, they’re avatars. But where do the boundaries between a person’s first and second lives lie?

“To a large extent I feel she’s me, and vice versa. I can’t feel through her, but there’s a definite vicarious thrill with everything in SL, from exploring, to shopping, to yes, even sex.” This is Gwyon Stockton talking. In her first life she’s 28 years old, married and a self-described “dismally boring secretary.” In her second life, she’s chosen a different profession.

“The first thing I did when I got in-world was look for a job. I looked at the options available at several different clubs and finally decided that I’d make a pretty good escort,” explains Gwyon. “After all, I’ve been having cybersex (in BBSs, Webchats, chatrooms and IMs) since I was a teenager - I should be good at it by now!”

To Gwyon, there’s nothing dehumanising or demeaning to what she’s doing, and the exploitation that exists in real world prostitution doesn’t cross over into SL.

“I’ve heard stories about girls who said that [prostitution] was all they were capable of, but most of the girls I know don’t do it for just the money, but because they enjoy it. It’s not like there aren’t other ways to get money here. You could camp, or go into real estate, or retail, or even just buy the Linden Dollars.”

It’s a fair point. The in-world currency is in plentiful supply, and it’s actually possible to get a job sitting down. Plus, if you don’t feel like even that kind of work, presumably anyone who can afford a computer and a broadband internet connection can also afford the relatively cheap price of the Linden dollar.

Some things, however, do carry over from the real world. “Misogyny exists here to some extent,” says Gwyon. “Some clubs treat their girls like meat, and it can be a bit harsh.” For all the technical chicanery and benefits, it’s the bigotry people bring with them that makes sex in Second Life so disappointingly recognisable.

Poker? I hardly know ‘er! Boom boom.
Back at the escort shopping centre, I select one of the women currently advertised as online on the posters. Blonde and around five foot tall, she is one of the more generic looking women available - possessing neither the gothic dominatrix nor wilting flower look that seem equally popular among the other pictures on display. She is traditional, in a white top, short skirts and boots, and her name is Lola.

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Lola will be my first, and to date my only, virtual sex partner.

After we talk for a little while and agree a price - 1,000 Lindens for 30 minutes with her, or just under £2 - she teleports us back to her place. It’s another large mansion, the second I’ve been in this evening, but this time there are no other people around. It’s just the two of us, and while I have seen many naked digital women on my journey so far, and even a daisy-chained foursome of mostly men at one unfortunate point earlier in the evening, I am now faced with having to do the do myself.

We move upstairs and into a large bedroom that I can’t imagine anyone sleeping in. The bed is floor level and equipped with straps and poseballs, and around the edges of the room lie a number of frightening looking contraptions that all appear to involve some form of bondage.

Lola leads me over to a large, commanding chair in the centre of the room, and directs me to sit. I use the poseball, and my character relaxes. “Is it an Xcite?” she asks. I reply that it is, and she gets to work. Or at least, she tries to.

Between my legs a head is bobbing away, but nothing is happening. I’m completely limp.

Uh oh. This is not what is meant to happen. I know what is meant to happen; I’ve read the owner’s manual. After a lascivious road trip through the twisted carnival world of Second Life, I have finally arrived in an upstairs room of a call girl’s mansion, I’m surrounded by stocks and swings, and I bought genitals from a strange naked man especially for this occasion. The latest addendum to my avatar should be responding. Why is it not responding?

“I keep clicking it and… nothing,” she says.

Not what a man wants to hear. I’m impotent. I am less than man. I am sitting in an office chair, slouched in front of a computer, watching a £2 call girl try in vain to get so much as a twitch out of me. WHY IS IT NOT RESPONDING?

Then I check the messages. She’s being rejected. Not by me, by it. I’m being cockblocked by my own e-penis. Lola isn’t on the permissions list, and in an attempt to dissuade would-be grabbers and pokers, only authorised people may excite your Xcite!. “Hold on,” I say, “I think I can fix it.” I dive into the script that handles the core processes and quickly add a line, with appropriate syntax, that allows Lola full and unreserved access to me and my little me.

She tries again. “Still nothing,” she says. Arse. But it’s too late now anyway, time is running out and if I want to salvage anything from this attempted coupling then we’re going to have to resign ourselves to my condition. There is no viagra in Second Life.

So that’s how we continue, moving from position to position, from swing to stocks, from straps to chains, with my most important position still firmly unfirm. We’re dry humping, and for all the sex talk, enthusiastic on her part and awkwardly meek on mine, I’m still slouched in front of my PC, looking depressedly at the screen.

Setting aside issues of gender bias, of misogyny and mistreatment, of the vagaries of first and second life boundaries, the one, clear thing I’m earning about all of this is that sex in MMO games is absurd. I can objectively understand how someone might enjoy this, how if they were to commit themselves to the fantasy then perhaps, yes, this could be exciting. But I feel detached, and silly, and self-conscious, and even a little bored. Were I to know this person, have an actual connection to them, then I can imagine this might be fun, an emotive process or an extension of our relationship. But it’s not. I don’t know this woman from Eve, aside from the fact I’m fairly sure Eve didn’t do it from behind.

I even introduce a poseball I had brought with me in the hopes of feeling more involved, but although she gladly participates, I feel completely disconnected from the process. My avatar is not me.

It’s not until 40 minutes in, ten minutes after we’re meant to be finished, that a realisation hits me. It’s never going to stop. My Xcite! Cock can’t reach climax, because it’s limp and Lola can’t interact with it. There isn’t going to be any disappointing sunlight for the particle effect to mourn. There isn’t going to be a particle effect at all, and while I’ve manipulated Lola’s own Xcite! devices so she could climax, I never will. I’m just trapped here, in this monotonous, repeating animation. Forever. Unless, of course, I end it.

So I do. I don’t disengage or sign-off. I fake orgasm. Through a series of even more awkward messages sent moaning through the in-game chat system, I bring the session to a close by pretending I’m satisfied. I feel like we both need the closure, but I can’t help but be reminded of what Gwyon had said earlier, when talking of how much her acts in Second Life actually affected her in the real world.

“Do I actually ‘get off’? Hell yes. For the most part, I do get excited and… entertain myself. That’s the point, for me at least. To have fun at it.”

Technically I have been entertained, but perhaps not in the way anyone had in mind. Certainly not in the way I had paid for.

Not only could my supposedly modern Major General not stand at attention, but he couldn’t salute either. This is a virtual fantasy. Things like this aren’t supposed to happen. It’s the enlightened new world and the last sexual frontier; no rape, no disease, no exploitation. Yet despite all the differences, it turns out that even in a digital world you can still give up your dignity in pursuit of the big O.

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Billboard: ‘Life’s Short — Get A Divorce’

May 8, 2007

At least, that’s what an all-female local law firm recommends in a new billboard situated near “Viagra Triangle,” a bustling, upwardly-mobile area of downtown known as a place men can pick up women.

The billboard for divorce lawyer Corri Fetman’s firm is turning heads here in Chicago.

It’s likely in part due to the suggestive pictures of cleavage and a man’s 6-pack hanging suggestively over Gibson’s Steakhouse, but also because of the message some feel it portrays.

Critics say the billboard promotes divorce, but Fetman said she just wants people to live with integrity.

“The message really is that life is very, very short, and you need to be honest with yourself and have some personal integrity,” said Fetman. “If you are unhappy, take some action and do something about it.”

“If you plan on getting divorced why get married?” one restaurant customer said.

“I think it’s great. It shows they’ve got guts and it gets your attention,” said another. “And the people are hot.”

“There’s no commitment these days,” said one man. “It shows a lack of commitment.”

Fetman and her partner Kelly Garland said the billboard is meant to be taken lightheartedly.

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But some, like the Womens Bar Assocication’s president, are not impressed.

“Lawyers already have a bad name. It un-dignifies lawyers,” Karen McNulty said. “It takes lightly the issue of divorce. It’s more disappointing than shocking.

Attorney Mike Berger said divorce is a time of great stress, and that this is “nothing more than a beer commercial.”

“I don’t find it gutsy … it’s distasteful,” he said. “This makes light of the situation and promotes divorce.”

But Attorney Rico Mirabelli likened the ad to a car ad and said it was placed in a populated area for a reason.

“It’s not going to make anyone go out and get a divorce,” he said.

As for Fetman, she says, “Everyone’s entitled to their own opinion. If you don’t like it, don’t look.”

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