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ED Drugs May Boost Orgasm Hormone

August 30, 2007

New research shows that erectile dysfunction drugs such as Viagra, Levitra, and Cialis may increase production of oxytocin, a reproductive hormone released during orgasm.

That news comes from scientists at the University of Wisconsin at Madison. They tested sildenafil (Viagra’s active ingredient), vardenafil (Levitra’s active ingredient), and a related chemical called T-1032 in lab tests on rats.

The researchers exposed part of the rats’ pituitary gland to those chemicals (which are called PDE5 inhibitors) and to mild electrical stimulation. Under those conditions, the rats’ pituitary glands produced more oxytocin.

Does that happen in people, too? This study doesn’t answer that question.

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But that topic deserves further study, since oxytocin is important in various reproductive functions, write researcher Meyer Jackson, Ph.D., and colleagues.

Their study shows no signs of increased oxytocin production without stimulation.

“Erectile dysfunction drugs do not induce erections spontaneously; they enhance the response to sexual stimulation,” Jackson states in a news release.

“The same thing is happening in the [rats’] posterior pituitary - Viagra will not induce the release of oxytocin on its own, but it will enhance the amount of release you get in response to electrical stimulation,” states Jackson.

Their findings appear in the Aug. 9 advance online edition of the Journal of Physiology.

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Viagra spam edges out pump-and-dump

August 18, 2007

Pump-and-dump spam, which dominated inboxes in the first half of the year, has given way to image spam and messages pushing ’sexual enhancement’ drugs, according to a report from security firm BitDefender.

In the seven months since January, BitDefender found that 75 per cent of all image spam was penny-stock related, while text-based spam was the preferred choice for drug-related topics.

Spam messages for sexual enhancement and weight loss drugs accounted for 56 per cent of all text spam. This was followed by spam hawking replica watches, which came third in BitDefender’s image and text spam lists.

New types of spam have also emerged in 2007, most notably hosted-image spam, which instead of containing an image provides a link to a website hosting the spam.

Spam with attachments, such as a PDF file, has also become more prevalent since the beginning of 2007.

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The latest measures used by spammers to try to defeat filters are malformed mail boundaries, which make it hard to unpack emails for inspection, and the use of malformed HTML code in an attempt to confuse parsers.

So-called Bayes poisoning and word obfuscation were used less frequently than in previous years, according to BitDefender.

Vlad Valceanu, head of BitDefender’s Antispam Laboratory, said: “Spammers are emailing fewer targets at a time, while introducing small variations in every email in the hope of avoiding timely detection.

“We expect to see more of this in the next half of the year, as well as increased use of attachments and possibly even embedded Flash.”

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Viagra: a cure for jet lag?

August 15, 2007

Max Davidson has something in common with that globetrotting football star David Beckham: jet lag. Can Viagra keep them perky?

I never thought I would find myself writing this, but it is the literal truth. David Beckham and I have the same problem - and Viagra could be the answer to it.

Air Viagra, is viagra a cure for jet lag?

Now plying his trade in Los Angeles, the footballer still hopes to play a key role in England’s qualifying campaign for the 2008 European Championships, which resumes in four weeks. On form, our boy Becks probably merits selection. But is it realistic to expect him to give of his best when he has just got off a 13-hour flight from Los Angeles?

Jet lag, as every frequent flier knows, can be a killer. In my case, it nearly was. I have never handled transatlantic flights well and in 2006, straight off a flight from the Caribbean, I paid the price. I was driving through Wiltshire at three in the afternoon, nodded off at the wheel and crashed into the car in front. Mercifully, nobody was hurt.

Naturally, with my history, a story in The Daily Telegraph on May 22, about how Viagra could perk up jet-lagged travellers, leapt out at me over the breakfast table. Could this be the answer to my prayers? Within hours, I was round at my doctor’s surgery, clutching the newspaper.

“Viagra?” My GP looked dubious. “As a cure for jet lag?” “It’s all right,” I said hastily. “There’s been some proper research.” “Done by whom?” “Scientists in Buenos Aires.” “And where was it published?” “The, er, Proceedings of the National Academy of Sciences. An American periodical. It’s not The Lancet, but…” No, he said, it certainly wasn’t The Lancet. He shot me a suspicious look. “You’re not…?” Our eyes met across the consulting room. Alpha male looked at alpha male.
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“No,” I said firmly. “I’m not. Two children under my belt. No problems in that department.” “Well, in that case…” Rather magnanimously in the circumstances, he scribbled out a prescription. “Let me look up the original research and email it to you.” Twenty-four hours later, he was as good as his word. “These findings only relate to hamsters,” ran his email. “I am not impressed.” Sure enough, the Buenos Aires researchers who had blazoned forth their findings to the world had confined their study to rodents. What had they done? Flown hamsters to Australia, then taken their blood pressure?

In fact, when one studied their paper, they had been far more ingenious. They had confused laboratory hamsters by switching on their lights early, given half of them Viagra, then observed the results. The hamsters on Viagra, intriguingly, were up and pounding their exercise wheels faster than the ones not on Viagra. Even more intriguingly, the Viagra only worked when west-to-east flight patterns - for example, Los Angeles to London - were simulated.

The other way round, the hamsters didn’t respond. Something to do with their circadian rhythms - body clock, to you and me.

Was it conceivable that these poor drugged creatures were trying to tell us something? As I was about to fly from London to Kuala Lumpur - 12 hours west to east, almost identical to the trip Beckham will have to make from Los Angeles - I decided to put the matter to the test.

Never again. First came the walk of shame to the chemist. “That will be £55,” said the pharmacist, looking at me as if I was Hannibal Lecter.

Fifty-five quid! I could have flown to Venice for that. His assistant, a young Asian woman, couldn’t bring herself to look me in the eyes.

Then came the experiment proper, mimicking the methods of the Buenos Aires team.

I normally struggle mid-afternoon after a long west-to-east flight, so at exactly 15.00 hours on my first day in Kuala Lumpur, I gave myself a small dose of Viagra, fed my partner a placebo of chocolate brownie and awaited developments. Hopeless. We both fell asleep an hour later, within five minutes of each other.

The next day, I doubled the dose of Viagra and gave my partner a placebo of white wine and pretzels. Again, hopeless. Apart from feeling a momentary twinge of lust for a Malaysian waitress who had left me cold the day before, I felt no discernible effects or side-effects.

On the third day, I did feel slightly perkier than I usually do in the early stages of jet lag. But perky enough to embrace Viagra as a cure for the condition? No way. Those boffins in Buenos Aires need to go back to the lab and experiment with something larger than hamsters. Horses perhaps. Or, better still, rhinoceroses.

I’m keeping an open mind. If David Beckham thinks that Viagra will help him combat jet lag as he whizzes to and from Los Angeles, let him give it a try. But he should (a) make sure he gets the dose right; and (b) consult his physician if he starts to feel unnatural cravings for the opposition left-back.

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A step closer to his dream

August 7, 2007

Internationally known sexual-medicine expert Dr. Irwin Goldstein has landed in San Diego, where his medical practice and research will place the city at the center of an effort to establish sexual medicine as a formally recognized medical discipline.

PEGGY PEATTIE / Union-Tribune
After spending three decades in Boston, sexual-medicine expert Dr. Irwin Goldstein has landed in San Diego, where he is creating a center to treat and study sexual problems at Alvarado Hospital.
It’s been about two years since the 57-year-old urologist left Boston University, where he spent three decades pioneering research on impotency and female sexual dysfunction.

Working out of Alvarado Hospital and as a volunteer instructor at the University of California San Diego School of Medicine, Goldstein wants to make the city a destination for people seeking treatment for sexual problems and for those who want to do research in the field.

In addition to naming Goldstein director of sexual medicine at Alvarado, the hospital’s owners have promised to fulfill the doctor’s long-standing dream of creating what could be the first department of sexual medicine in the country.

Goldstein on Monday will open his private practice on the campus of the College Area hospital with a modest staff that includes a certified sex therapist, a nurse practitioner and a medical assistant.

OVERVIEW

Background: Internationally renowned sexual-medicine physician Irwin Goldstein has relocated to San Diego, opened a private practice and been named head of sexual medicine at Alvarado Hospital.

What’s changing: Goldstein hopes to make San Diego a center for treating and studying sexual dysfunction as well as for training other physicians in the field.

The future: Establishment of a sexual-medicine department at Alvarado – possibly the first in the country – could help lead to the recognition of sexual medicine as a formal medical specialty.
He says he hopes the business will grow into a center for treatment, research and training, not unlike the 5,000-patient Institute for Sexual Medicine that he created and oversaw at the Boston University School of Medicine until May 2005.

“What he is going to be doing here is transforming our understanding of sexual medicine,” said Dr. Pedram Salimpour, one of Alvarado Hospital’s owners.

With some research suggesting that nearly half of all women and more than a third of all men experience sexual dysfunction at some point in their lives, the need for physicians with special training in the field is increasingly coming into focus, said Dr. Ira Sharlip, a clinical professor of urology at the University of California San Francisco who counts Goldstein among his friends.

“What we hope will occur is that sexual medicine will become a well-recognized and respected specialty in the panoply of medical specialties,” Sharlip said. “It is a serious medical specialty with its own vocabulary, set of clinical conditions, treatments and biochemistry.”

Some critics, however, say that much of the push to medicalize sexual problems is coming from drug companies seeking new markets, particularly among women.

PEGGY PEATTIE / Union-Tribune
Irwin Goldstein’s new ID notes that his practice is sexual medicine.
“Female sexual dysfunction is a concocted term,” said Dr. Leonore Tiefer, an associate professor of psychiatry at the New York University School of Medicine. “It’s all been sort of the cart leading the horse.

For sexual medicine to gain legitimacy, she said, it must expand beyond the narrow focus of treating people who have difficulty having sex and include other related matters, such as sexually transmitted diseases, gender identity problems, fertility issues, and rape and sexual-abuse issues.

“I don’t think that creation of this thing as sexual medicine is the right thing at the right time for the public,” Tiefer said.

For now, sexual medicine remains outside the 130 specialties recognized by the American Medical Association. Doctors who practice in the field must specialize instead in a related recognized area, such as urology, obstetrics and gynecology, neurology or endocrinology.

That can lead to practical problems, Goldstein said.

At Boston University, he encountered obstacles that made it difficult for him to work with physicians outside the Department of Urology, which oversaw his sexual-medicine institute. “I had handcuffs everywhere I went,” he said.

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While there is nothing unusual about bureaucratic walls between medical specialties, the divisions at Boston University became untenable for Goldstein.

He was operating in a world in which a growing body of research was linking sexual dysfunction to cardiovascular disease, neurological problems, hormone deficiencies and other physiological conditions. He believed that the evolution of sexual medicine demanded more cross-specialty collaboration than was possible in traditional academic medicine.

Differences over those strictures eventually led to his departure from Boston University.

“Dr. Goldstein made a number of requests to the medical center regarding department organization,” Boston University School of Medicine spokeswoman Ellen Berlin wrote at the time of the doctor’s departure. “The medical center was unable to reach an acceptable agreement with Dr. Goldstein and therefore decided not to continue his contract.”

Goldstein said the parting of ways was mutual. “You have to look in the mirror and say, ‘I could spend the rest of my life in the Department of Urology’ . . . or I could say, ‘I’m not willing to do that anymore.’ I chose to pursue my dream,” he said.

Goldstein said a search for a new home in the academic world took a year and a half, and included discussions with Cedars-Sinai Medical Center in Los Angeles and the University of California Irvine Medical Center. Those talks came up empty because most teaching hospitals were unwilling to give him the level of independence he sought.

Then in late 2006 he received a call from Salimpour, a Los Angeles pediatrician who had worked as Goldstein’s research assistant in the late 1990s.

An investor group headed by Salimpour and his older brother, Pejman Salimpour, also a Los Angeles pediatrician, was preparing to purchase Alvarado Hospital for $22.5 million. The hospital had been forced into a sale by federal authorities after several years of legal and financial difficulties.

Goldstein was scheduled to visit San Diego on behalf of Pfizer, the maker of Viagra, for a grand round – a meeting with other doctors to discuss his latest clinical work. The gathering was set for mid-January, a few weeks after the Salimpours were to close the hospital deal.

Hoping to garner positive attention for Alvarado within the medical community, Pedram Salimpour asked his friend and mentor to conduct the grand round at the College Area hospital. During the dinner that followed, the Salimpours proposed that Goldstein consider moving to San Diego and opening a new practice at Alvarado.

By the end of the next day, Goldstein and the Salimpours had hammered out a deal that promised the sexual-medicine expert the freedom and flexibility he desired.

Goldstein and the Salimpours would not say whether any financial arrangement exists between the doctor and the hospital. Under California law, hospitals are generally barred from directly employing physicians.

Having Goldstein on Alvarado’s medical staff will undoubtedly increase the hospital’s visibility and could boost its reputation, which suffered under previous owner Tenet Healthcare.

Goldstein is often quoted in articles about sexual medicine that appear in publications around the world, and he is editor-in-chief of The Journal of Sexual Medicine, the most influential publication in the field. Both San Diego and Alvarado are listed under the doctor’s name on the credits page of the journal.

“This shows everyone that we are pioneers and innovators,” Pedram Salimpour said.

Goldstein’s arrival also could have a more practical effect on the 306-bed hospital. Surgical procedures performed by the doctor, such as penile implants, and his research activity will help bring in patients. And many of his patients might be referred to other specialists who practice at Alvarado, Goldstein said.

On a recent afternoon in an Alvarado meeting room, Goldstein fiddled with an identification card hanging from the breast pocket of his sport coat. Made an hour earlier, the tag showed his photograph, his name and the words “sexual medicine” printed along the bottom. In Boston, his ID had read “urology.”

Goldstein smiled broadly as he cradled the new tag.

“This card doesn’t exist anywhere,” he said. “I went into the bathroom and stared at it in the mirror.

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Suit blames Viagra for vision loss

August 2, 2007

A Denver man has sued the company that makes Viagra, saying the erectile dysfunction drug caused a stroke that deprived him of vision in one eye.

Thomas Parker filed the suit in U.S. District Court in Denver on Tuesday against Pfizer Inc.

Parker’s complaint alleges that Pfizer failed to notify consumers of the potential side effects and has downplayed those risks.

Neither Parker, his lawyer nor a Pfizer representative could be reached for comment.

The suit contends that Viagra contains “unreasonably dangerous design defects.” It also states that Pfizer knew of and failed to use a safer design and ingredient for Viagra.

On July 8, the FDA approved updated labeling for Cialis, Levitra and Viagra to reflect what the agency described as a “small number” of reports of sudden vision loss attributed to a condition in which blood flow is blocked to the optic nerve.

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The FDA advisory cautioned patients taking the medication to consult with a doctor or health care provider if they experienced a sudden or decreased loss of vision in one or both eyes.

The advisory also stated that it is “not possible” to determine whether those drugs were responsible for the vision loss, citing other possible factors such as high blood pressure, diabetes or a combination of these problems.

According to Business Week, Americans consumed $434 million worth of Viagra in the first three months of 2007, an increase of 11 percent over the same period last year.

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